Well, I am not sure what you mean by help... there are millions of possibilities.. you need to be a little more accurate..
I think if you are unfamiliar with painting in general, you should put your wacom down, and go take some art classes.. go get a few sketch books and start sketching..
but if you can draw and such.. and just need help learning the software, you can go to the top button "HELP" and click on tutorials, and that will help you out..
I also suggest you just start trying to figure out the software by yourself.. experimenting and time is the key.. Its better to learn it on your own..
if you read through this forum there is tons of info..
good luck, and if you have specific questions don't hesitate to ask.
"Live each day like you will die tommorow, and dream like you will live forever..."