I guess I should feel fortunate to not have used any other previous Cintiqs prior to my 22HD, because I don't have any issue at all with the screen. Yes, it's a bit grainy when I stick my face within 10 inches of it, but with my poor eyesight and Coke-bottle glasses, I can't really see much when I'm that close anyway. My normal distance from the screen is around 16 to 18 inches, and at that distance, the graininess is not an issue at all. If I took my glasses off, I'd never be further than 3 inches from the screen, and I'd be complaining constantly about that, and my sore neck
But really, I love this thing!
My only complaint is the low Adobe RGB color compatibility. I'm still working on a reliable work-around on that (establishing adjustment steps when I transfer the image to my other monitors for pre-print work), but I don't think it's a huge issue, since I'm used to such adjustments anyway.
Last night I slept like a baby: I wore a diaper.