Okay, I'm not sure about anyone else, but I'm reading 3 light sources here of varying intensity with no values relative to the light reflecting from them. The brightness of the figure isn't working with the relatively ambient background. It's pretty obvious we have a light source coming from straight above giving nice contrast to the figure but why is the background so dark?
Also, the face is flat. The edges need to be softened and you need more colors too in order to give it the same style. The face is more abstract and almost cubist, and the rest looks like something cool I'd see in Silent Hill.
Next, whatever is happening at her feet - it looks like something glowing. That needs to be more developed (especially since that background and the figure both look highly developed).
Lastly, composition wise this is actually pretty boring IMO. Straight on, dead center, not much happening and the creature here is smiling and just sort of being there. I'm also not sure I really know what's going on - we just need more information. You've done so much up to this point, that I'm not sure what to tell you - even though I think this is digital so changes should be pretty easy. Maybe make the creature appear to be coming at us, while smiling, but we can tell it's a more threatening manner (give her completely black eyes, and make it look like that giant claw is being hidden from us, maybe some sharp teeth in a smile). Or, have it a completely innocent look, hiding the "I'm going to cut you into little pieces" and we can sort of see past the innocent thing straight into the "I better do something before any of this monsters body parts get close to me). Then again maybe this is a friendly devil may cry character who really does want to help. No danger at all - which is what's being projected right now.
Just my thoughts. Hope I wasn't too too harsh.
Doctors heal you, Artists immortalize you.
"Those who can, do. Those who can't, teach" - bullshit.
The usual staples for anatomy: