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I didn't use wacom; I used genius tablet, but SAI wouldn't work with dual monitor. All other programs work except SAI. I tried play around with the misc.ini, but it only correct the cursor's position appearance on the 2nd monitor. When I actually paint it, I could notice that the brush was off and is extended to both monitor's screen range. How do I get over this problem?
I don't know since you're using a non-wacom tablet. I didn't have any problems running Sai on 2 monitors.